Article

Vertical Sleeve Gastrectomy inhibits 11βHSD1 and subsequently reduces IL6 secretion in Mice and Humans: A Shared Anti-Inflammatory Mechanism

2026-05-15

Abstract excerpt

<h4>Background</h4> Vertical sleeve gastrectomy (VSG) improves glycaemic control in type 2 diabetes (T2D) through mechanisms that extend beyond weight loss. The interaction between glucocorticoid metabolism and inflammation in this context remains unclear. <h4>Methods</h4> We investigated the role of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) in mediating the metabolic effects of VSG in humans and mice. S...

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Literature Corpus work: efcf0011-3cd2-5319-9288-2a90ff13d840
DOI: 10.64898/2026.05.12.724611

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