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Article

Host FIH-Mediated Asparaginyl Hydroxylation of Translocated Legionella pneumophila Effectors.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Price Christopher, Merchant Michael, Jones Snake, Best Ashley, Von Dwingelo Juanita, Lawrenz Matthew B, Alam Nawsad, Schueler-Furman Ora, Kwaik Yousef A

Abstract excerpt

FIH-mediated post-translational modification through asparaginyl hydroxylation of eukaryotic proteins impacts regulation of protein-protein interaction. We have identified the FIH recognition motif in 11 Legionella pneumophila translocated effectors, YopM of Yersinia, IpaH4.5 of Shigella and an ankyrin protein of Rickettsia. Mass spectrometry analyses of the AnkB and AnkH effectors of L. pneumophila confirm their...

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Identifiers

PMID: 28321389
DOI: 10.3389/fcimb.2017.00054
PMCID: PMC5337513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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