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Metabolic reprogramming and immunosenescence in colorectal cancer: mechanisms and therapeutic implications

13 Aug 2025

Abstract excerpt

Colorectal cancer (CRC), as a highly prevalent malignant tumor worldwide, has a persistently high incidence and mortality rate. In recent years, metabolic reprogramming and immunosenescence have received extensive attention as key mechanisms for tumorigenesis, development and treatment resistance. Metabolic reprogramming not only provides energy and biosynthetic precursors for tumor cells, but also regulates...

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PMID: 40881346
DOI: 10.3389/fcell.2025.1662464

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