Article

ADGRG1 blockade drives astrocyte positioning into the extracellular matrix to reduce scar size

2025-12-22

Abstract excerpt

After the central nervous system (CNS) injury, inflammatory cells enter the lesion core and a fibrotic extracellular matrix accumulates. Astrocytes subsequently cluster around this matrix, forming a glial scar, but the role of the extracellular matrix in scar formation remains poorly understood. Here, we identify type III collagen, a major fibrotic extracellular matrix component after spinal cord injury, as a key...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ab42813-162f-55a6-8e0f-9ae136a3debe
DOI: 10.64898/2025.12.18.695114

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ADGRG1 blockade drives astrocyte positioning into the extracellular matrix to reduce scar sizeDOI 10.64898/2025.12.18.695114Read

ADGRG1 blockade drives astrocytes into the extracellular matrix to reduce glial scar sizeSemantic proximity Read

Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injurySemantic proximity Read

Spatiotemporal heterogeneity and protective polarization of astrocytes depending on intercellular interaction after intracerebral hemorrhageSemantic proximity Read

A molecular brain atlas reveals cellular shifts during the repair phase of strokeSemantic proximity Read

BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury ResponseSemantic proximity Read

Lesion-remote astrocytes govern microglia-mediated white matter repairSemantic proximity Read

Molecular basis of astrocyte diversity and morphology across the CNS in health and diseaseSemantic proximity Read

Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues.Semantic proximity Read

Single‐cell RNA sequencing for traumatic spinal cord injurySemantic proximity Read

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cordSemantic proximity Read

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesionsSemantic proximity Read

Amphiregulin promotes remyelination by reprogramming microglia and priming OPC differentiationSemantic proximity Read