Article

A computational study of the fold and stability of cytochrome c with implications for disease

2024-07-24

Abstract excerpt

Cytochrome c (Cyt-c), encoded by the CYCS gene, is crucial for electron transport, peroxidase activity, and apoptosis. Mutations in CYCS causes thrombocytopenia 4, a disorder with low platelet counts. We have, for instance, recently described six Italian families with five different heterozygous missense CYCS variants. These mutations likely enhance peroxidase and apoptotic activities, yet the mechanisms causin...

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Literature Corpus work: 99f469ae-6927-5870-af41-443c50422114
DOI: 10.1101/2024.07.24.604913

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