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Article

Investigation of structural dynamics of Thrombocytopenia Cargeeg mutants of human apoptotic cytochrome c: A molecular dynamics simulation approach.

Biophysical chemistry - 1 Nov 2017

Muneeswaran Gurusamy, Kartheeswaran Subramanian, Pandiaraj Manickam, Muthukumar Kaliappan, Sankaralingam Muniyandi, Arunachalam Saravanavadivu

Abstract excerpt

Naturally occurring mutations to cytochrome c (cyt-c) have been identified recently in patients with mild autosomal dominant thrombocytopenia (low platelet levels), which yield cyt-c mutants with enhanced apoptotic activity. However, the molecular mechanism underlying this low platelet production and enhanced apoptosis remain unclear. Therefore, an attempt is made herein for the first time to investigate the...

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PMID: 28958449
DOI: 10.1016/j.bpc.2017.09.004

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