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Article

Differences in functional cross-talk between loops C and D in two mitochondrial cytochromes.

Journal of inorganic biochemistry - 1 Mar 2026

Shin Dong-Woo, Zhong Fangfang, Pletneva Ekaterina V

Abstract excerpt

The heme in the protein cytochrome (cyt) c is surrounded by loops C and D that differ in their sequences across species. Mutations G41S and Y48H in human (hu) cyt c are associated with thrombocytopenia and have been extensively studied. Herein, we describe effects of the same mutations in horse heart (hh) cyt c and make comparisons to those in the hu protein. While wild-type (WT) hu and hh cyt c proteins have...

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Topics

Horses
Cytochromes c
Humans
Animals
Molecular Dynamics Simulation
Mutation
Heme

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Identifiers

PMID: 41411686
DOI: 10.1016/j.jinorgbio.2025.113182
PMCID: PMC12768443

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