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Article

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs.

Protein & cell - 1 Mar 2018

Yang Yi, Wu Han, Kang Xiangjin, Liang Yanhui, Lan Ting, Li Tianjie, Tan Tao, Peng Jiangyun, Zhang Quanjun, An Geng, Liu Yali, Yu Qian, Ma Zhenglai, Lian Ying, Soh Boon Seng, Chen Qingfeng, Liu Ping, Chen Yaoyong, Sun Xiaofang, Li Rong, Zhen Xiumei, Liu Ping, Yu Yang, Li Xiaoping, Fan Yong

Abstract excerpt

Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestations. Mitochondria-targeted endonucleases provide an alternative avenue for treating mitochondrial disorders via targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29318513
DOI: 10.1007/s13238-017-0499-y
PMCID: PMC5829275

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