Article

Switch-like methylation of functional pathways distinguishes COPD and idiopathic pulmonary fibrosis

2025-12-19

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are phenotypically divergent disorders arising from similar exposures (including cigarette smoke). Differences in DNA methylation may drive the exposed lung towards COPD vs. IPF. To characterize differential methylation in COPD and IPF lung tissue relative to controls, we conducted epigenome-wide association studies of COPD and IP...

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Literature Corpus work: 6a7b5c75-70d2-506d-997a-2a18bf281f5a
DOI: 10.64898/2025.12.18.25342312

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