Article
DNA Methylome Alterations Are Associated with Airway Macrophage Differentiation and Phenotype during Lung Fibrosis.
American journal of respiratory and critical care medicine - 15 Oct 2021
McErlean Peter, Bell Christopher G, Hewitt Richard J, Busharat Zabreen, Ogger Patricia P, Ghai Poonam, Albers Gesa J, Calamita Emily, Kingston Shaun, Molyneaux Philip L, Beck Stephan, Lloyd Clare M, Maher Toby M, Byrne Adam J
Abstract excerpt
Rationale: Airway macrophages (AMs) are key regulators of the lung environment and are implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a fatal respiratory disease with no cure. However, knowledge about the epigenetics of AMs in IPF is limited. Objectives: To assess the role of epigenetic regulation of AMs during lung fibrosis. Methods: We undertook DNA methylation (DNAm) profiling by using...
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