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High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD

5 May 2023

Abstract excerpt

Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering its environmental cause, we hypothesized that COPD will be associated with altered epigenetic signaling in lung cells. We generated genome-wide DNA methylation maps at single CpG resolution of primary human lung fibroblasts (HLFs) across COPD stages. We show that the epigenetic landscape is changed...

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PMID: 37143403
DOI: 10.15252/embj.2022111272

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