Article

Epigenetic alterations underlie airway macrophage differentiation and phenotype during lung fibrosis

2020-12-04

Abstract excerpt

Airway macrophages (AMs) are key regulators of the lung environment and are implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a fatal respiratory disease with no cure. However, the epigenetics of AMs development and function in IPF are limited. Here, we characterised the DNA-methylation (DNAm) profile of AMs from IPF (n=30) and healthy (n=14) donors. Our analysis revealed epigenetic heterogene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0e5650a-8779-5fd3-9d2d-a7469bcd94d2
DOI: 10.1101/2020.12.04.410191

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic alterations underlie airway macrophage differentiation and phenotype during lung fibrosisDOI 10.1101/2020.12.04.410191Read

DNA Methylome Alterations Are Associated with Airway Macrophage Differentiation and Phenotype during Lung Fibrosis.Semantic proximity Read

Epigenetics in lung fibrosis: from pathobiology to treatment perspective.Semantic proximity Read

DNA Methylation of Fibroblast Phenotypes and Contributions to Lung Fibrosis.Semantic proximity Read

Epigenetics of idiopathic pulmonary fibrosis.Semantic proximity Read

Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosisSemantic proximity Read

DNA methylation in pulmonary fibrosis and lung cancerSemantic proximity Read

Systemic and Airway Epigenetic Disruptions Are Associated with Health Status in COPDSemantic proximity Read

Interplay between genetics and epigenetics in lung fibrosisSemantic proximity Read

The heterogeneity of lung macrophages in the susceptibility to disease.Semantic proximity Read

Role of Epigenetics in Chronic Lung DiseaseSemantic proximity Read

Epigenomics of Idiopathic Pulmonary FibrosisSemantic proximity Read

Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1 <sup>+</sup> macrophagesSemantic proximity Read