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Article

Towards generalizable predictions for G protein-coupled receptor variant expression.

Biophysical journal - 19 Jul 2022

Kuntz Charles P, Woods Hope, McKee Andrew G, Zelt Nathan B, Mendenhall Jeffrey L, Meiler Jens, Schlebach Jonathan P

Abstract excerpt

Missense mutations that compromise the plasma membrane expression (PME) of integral membrane proteins are the root cause of numerous genetic diseases. Differentiation of this class of mutations from those that specifically modify the activity of the folded protein has proven useful for the development and targeting of precision therapeutics. Nevertheless, it remains challenging to predict the effects of mutations...

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Identifiers

PMID: 35715957
DOI: 10.1016/j.bpj.2022.06.018
PMCID: PMC9382327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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