Article

Structural and Functional Characterization of G Protein-Coupled Receptors with Deep Mutational Scanning

2019-04-30

Abstract excerpt

In humans, the 813 G protein-coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state, and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it challenging to understand their structure and function. Here we developed a platform to characterize large libraries of GPCR variants in human cell lines with a bar...

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Literature Corpus work: f72fa4c6-0644-50d6-b980-6280bce59918
DOI: 10.1101/623108

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