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Article

Triangulating variation in the population to define mechanisms for precision management of genetic disease.

Structure (London, England : 1993) - 4 Aug 2022

Wang Chao, Anglès Frédéric, Balch William E

Abstract excerpt

To understand mechanistically how the protein fold is shaped by therapeutics to inform precision management of disease, we developed variation-capture (VarC) mapping. VarC triangulates sparse sequence variation information found in the population using Gaussian process regression (GPR)-based machine learning to define the combined pairwise-residue interactions contributing to dynamic protein function in the...

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Identifiers

PMID: 35714602
DOI: 10.1016/j.str.2022.05.011
PMCID: PMC9357173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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