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Article

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

26 Jul 2022

Abstract excerpt

PURPOSE: Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored. EXPERIMENTAL DESIGN: We challenged 112 cell models recapitulating the genomic landscape of metastatic colorectal cancer with ATM, ATR, CHK1, WEE1, and DNA-PK...

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PMID: 35881546
DOI: 10.1158/1078-0432.ccr-22-0875

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