Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer.

doi:10.1053/j.gastro.2021.03.022

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Article

Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer.

Gastroenterology - 1 Jul 2021

Inoue Akira, Robinson Frederick S, Minelli Rosalba, Tomihara Hideo, Rizi Bahar Salimian, Rose Johnathon L, Kodama Takahiro, Srinivasan Sanjana, Harris Angela L, Zuniga Andy M, Mullinax Robert A, Ma Xiaoyan, Seth Sahil, Daniele Joseph R, Peoples Michael D, Loponte Sara, Akdemir Kadir C, Khor Tin Oo, Feng Ningping, Roszik Jason, Sobieski Mary M, Brunell David, Stephan Clifford, Giuliani Virginia, Deem Angela K, Shingu Takashi, Deribe Yonathan Lissanu, Menter David G, Heffernan Timothy P, Viale Andrea, Bristow Christopher A, Kopetz Scott, Draetta Giulio F, Genovese Giannicola, Carugo Alessandro

Abstract excerpt

BACKGROUND & AIMS: Understanding the mechanisms by which tumors adapt to therapy is critical for developing effective combination therapeutic approaches to improve clinical outcomes for patients with cancer. METHODS: To identify promising and clinically actionable targets for managing colorectal cancer (CRC), we conducted a patient-centered functional genomics platform that includes approximately 200 genes and...

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PMID: 33745946
DOI: 10.1053/j.gastro.2021.03.022
PMCID: PMC8238881

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