Article

A sequence-based method for predicting extant fold switchers that undergo α-helix <-> β-strand transitions

2021-01-16

Abstract excerpt

Extant fold-switching proteins remodel their secondary structures and change their functions in response to cellular stimuli, regulating biological processes and affecting human health. In spite of their biological importance, these proteins remain understudied. Few representative examples of fold switchers are available in the Protein Data Bank, and they are difficult to predict. In fact, all 96 experimentally va...

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Literature Corpus work: c232b8d8-f835-5995-b954-ac23082c6d3c
DOI: 10.1101/2021.01.14.426714

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