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Article

diffBUM-HMM: a robust statistical modeling approach for detecting RNA flexibility changes in high-throughput structure probing data.

Genome biology - 27 May 2021

Marangio Paolo, Law Ka Ying Toby, Sanguinetti Guido, Granneman Sander

Abstract excerpt

Advancing RNA structural probing techniques with next-generation sequencing has generated demands for complementary computational tools to robustly extract RNA structural information amidst sampling noise and variability. We present diffBUM-HMM, a noise-aware model that enables accurate detection of RNA flexibility and conformational changes from high-throughput RNA structure-probing data. diffBUM-HMM is widely...

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Identifiers

PMID: 34044851
DOI: 10.1186/s13059-021-02379-y
PMCID: PMC8157727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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