Article

A method for predicting evolved fold switchers exclusively from their sequences

2020-02-20

Abstract excerpt

Although most proteins with known structures conform to the longstanding rule-of-thumb that high levels of aligned sequence identity tend to indicate similar folds and functions, an increasing number of exceptions is emerging. In spite of having highly similar sequences, these “evolved fold switchers” (1) can adopt radically different folds with disparate biological functions. Predictive methods for identifying ev...

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Literature Corpus work: 455f5f4f-17fb-5496-a392-633a13c36e80
DOI: 10.1101/2020.02.19.956805

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