Article
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Nature communications - 29 May 2024
Mutlu Merve, Schmidt Isabel, Morrison Andrew I, Goretzki Benedikt, Freuler Felix, Begue Damien, Simic Oliver, Pythoud Nicolas, Ahrne Erik, Kapps Sandra, Roest Susan, Bonenfant Debora, Jeanpierre Delphine, Tran Thi-Thanh-Thao, Maher Rob, An Shaojian, Rietsch Amandine, Nigsch Florian, Hofmann Andreas, Reece-Hoyes John, Parker Christian N, Guerini Danilo
Abstract excerpt
Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its' involvement in a variety of diseases, STING has been a focus for drug discovery. Targeted protein degradation (TPD) has emerged as a promising pharmacology for targeting previously considered...
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