Article

Using Patient iPSC-derived Retinal Pigment Epithelial Cells to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy

2026-04-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Compare the effect of MEK inhibition on iPSC-derived retinal pigmental epithelial (RPE) cells generated from a patient who developed MEK inhibitor-Associated Retinopathy (MEKAR) versus a patient who did not develop retinopathy. <h4>Design</h4> Case-control <h4>Subjects</h4> Two female patients with Neurofibromatosis Type 1 who were treated with MEK inhibitors. One patient dev...

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Literature Corpus work: 6a0a0216-f3cc-505f-a925-2e64ae53ea75
DOI: 10.64898/2026.04.11.717944

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