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Article

Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells.

International journal of molecular sciences - 20 Feb 2021

Artero-Castro Ana, Long Kathleen, Bassett Andrew, Ávila-Fernandez Almudena, Cortón Marta, Vidal-Puig Antonio, Jendelova Pavla, Rodriguez-Jimenez Francisco Javier, Clemente Eleonora, Ayuso Carmen, Erceg Slaven

Abstract excerpt

Hereditary retinal dystrophies (HRD) represent a significant cause of blindness, affecting mostly retinal pigment epithelium (RPE) and photoreceptors (PRs), and currently suffer from a lack of effective treatments. Highly specialized RPE and PR cells interact mutually in the functional retina, therefore primary HRD affecting one cell type leading to a secondary HRD in the other cells. Phagocytosis is one of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33672445
DOI: 10.3390/ijms22042092
PMCID: PMC7923278

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