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Article

Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies.

Drug discovery today - 1 Sept 2018

Pavan Barbara, Dalpiaz Alessandro

Abstract excerpt

Retinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood-retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating...

Topics

Administration, Ophthalmic
Animals
Cell Line
Drug Delivery Systems
Drug Discovery
Gene Expression Regulation
Gene Transfer Techniques
Genotype
Humans
Molecular Targeted Therapy
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinal Diseases

Retinal Pigment Epithelium

Signal Transduction

Source

Identifiers

PMID: 29908265
DOI: 10.1016/j.drudis.2018.06.009

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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