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Article

Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies.

Drug discovery today - 1 Sept 2018

Pavan Barbara, Dalpiaz Alessandro

Abstract excerpt

Retinal pigment epithelium (RPE) is a cell monolayer essential for photoreceptor function and forming the blood-retinal barrier. RPE and retinal neurons share the same origin and a polarized cytoarchitecture. Several factors determine the phagocytosis and permeability of RPE, influencing photoreceptor renewal and drug delivery, efficacy and toxicity. Adult human RPE expresses neuronal markers in vitro, indicating...

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Identifiers

PMID: 29908265
DOI: 10.1016/j.drudis.2018.06.009

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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