Article

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

2021-01-07

Abstract excerpt

Sorsby Fundus Dystrophy (SFD) is a rare form of macular degeneration that is clinically similar to age-related macular degeneration (AMD), and a histologic hallmark of SFD is a thick layer of extracellular deposits beneath the retinal pigment epithelium (RPE). Previous studies of SFD patient-induced pluripotent stem cell (iPSC) derived RPE differ as to whether these cultures recapitulate this key clinical feature...

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Literature Corpus work: fce93c36-ec92-599a-9ca7-dc5510966398
DOI: 10.1101/2021.01.06.425613

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