Article

Retinal pigment epithelium exhibits cell size, gene expression, and phagocytic activity alterations when exposed to retinoblastoma chemotherapeutics

2022-08-16

Abstract excerpt

Retinoblastoma (Rb) is a rare malignant disorder affecting the developing retina of children under the age of five. Chemotherapeutic agents used for treating Rb have been associated with defects of the retinal pigment epithelium (RPE), such as hyperplasia, gliosis, mottling, and visual acuity. Herein, we have developed two pluripotent stem cell (PSC)-RPE models to assess the cytotoxicity of known Rb chemotherapeut...

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Literature Corpus work: 8afae9db-fb99-5e80-a327-34a54c461ea9
DOI: 10.21203/rs.3.rs-1886208/v1

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