Article

Modeling MEK inhibitor-Associated Retinopathy <i>in vitro</i> using human induced pluripotent stem cell-derived retinal pigment epithelial cells

2025-10-04

Abstract excerpt

Pharmacologic inhibitors of MEK are important anti-cancer drugs but can result in MEK inhibitor-Associated Retinopathy (MEKAR) in which vision is lost due to serous retinal detachments that form via an unknown mechanism. We hypothesized that the cause of this side effect is drug-induced dysfunction of retinal pigment epithelial (RPE) cells. To test this hypothesis, we used human induced pluripotent stem cell-deriv...

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Literature Corpus work: 729c2aaf-7d63-5956-8b94-a4f1bbc2319c
DOI: 10.1101/2025.10.03.680301

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