Article

Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery

2025-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Single domain antibodies, often known as nanobodies, are versatile molecules with therapeutic and diagnostic applications, but they are primarily developed through immunization of camelids. This approach is not scalable by automation, not effective for non-immunogenic or toxic antigens, and prevents the use of modified scaffolds for altered pharmacokinetic properties. Synthetic libraries allow f...

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Literature Corpus work: 1900e1eb-b843-5d08-9921-4e15bed525ea
DOI: 10.1101/2025.05.14.654066

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