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Article

A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors.

Scientific reports - 5 Jun 2015

Sharma Ankur, Gadkari Rupali A, Ramakanth Satthenapalli V, Padmanabhan Krishnanand, Madhumathi Davanam S, Devi Lakshmi, Appaji Lingappa, Aster Jon C, Rangarajan Annapoorni, Dighe Rajan R

Abstract excerpt

Higher Notch signaling is known to be associated with hematological and solid cancers. We developed a potential immunotherapeutic monoclonal antibody (MAb) specific for the Negative Regulatory Region of Notch1 (NRR). The MAb604.107 exhibited higher affinity for the "Gain-of-function" mutants of Notch1 NRR associated with T Acute lymphoblastic Leukemia (T-ALL). Modeling of the mutant NRR with 12 amino-acid...

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Identifiers

PMID: 26046801
DOI: 10.1038/srep11012
PMCID: PMC4457015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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