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Article

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA.

Cancer discovery - 1 Sept 2015

Harney Allison S, Arwert Esther N, Entenberg David, Wang Yarong, Guo Peng, Qian Bin-Zhi, Oktay Maja H, Pollard Jeffrey W, Jones Joan G, Condeelis John S

Abstract excerpt

UNLABELLED: Dissemination of tumor cells is an essential step in metastasis. Direct contact between a macrophage, mammalian-enabled (MENA)-overexpressing tumor cell, and endothelial cell [Tumor MicroEnvironment of Metastasis (TMEM)] correlates with metastasis in breast cancer patients. Here we show, using intravital high-resolution two-photon microscopy, that transient vascular permeability and tumor cell...

Read the complete abstract on PubMed

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Share to Capillary Permeability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Imaging

Share to Neovascularization, Pathologic

Share to Receptor, TIE-2

Share to Time-Lapse Imaging

Share to Tumor Microenvironment

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 26269515
DOI: 10.1158/2159-8290.CD-15-0012
PMCID: PMC4560669

Genes

VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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