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Identification of a minority population of LMO2 + breast cancer cells that integrate into the vasculature and initiate metastasis

9 Nov 2022

Abstract excerpt

Metastasis is responsible for most breast cancer–related deaths; however, identifying the cellular determinants of metastasis has remained challenging. Here, we identified a minority population of immature THY1 + / VEGFA + tumor epithelial cells in human breast tumor biopsies that display angiogenic features and are marked by the expression of the oncogene, LMO2 . Higher abundance of LMO2 + basal cells correlated...

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PMID: 36351009
DOI: 10.1126/sciadv.abm3548

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