Article

Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium

2021-12-17

Abstract excerpt

Misshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder. The altered RBC morphology likely influences their biomechanical properties which are crucial for the cells to pass the microvasculature. Here, we investigated blood cell deformability of 5 ChAc patients compared to healthy...

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Literature Corpus work: 45379ebe-697b-59dc-b32d-b79e9bb2b1c2
DOI: 10.1101/2021.12.16.472921

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