Article

Huntington’s disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion

2025-07-18

Abstract excerpt

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by inheriting an expanded CAG repeat tract in the huntingtin gene ( HTT ) that further expands in somatic cells over an individual’s lifetime. Genome-wide association studies have provided critical insight into factors that modify the course of disease. These include DNA repair genes that alter the rate of somatic expansion and other genes tha...

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Literature Corpus work: 2f934ff6-9f9f-5c92-87fa-aa402c2deb44
DOI: 10.1101/2025.07.15.664798

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