Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data

Abstract excerpt

Antibody next-generation sequencing (NGS) datasets have become crucial to develop computational models addressing this successful class of therapeutics. Although antibodies are composed of both heavy and light chains, most NGS sequencing depositions provide them in unpaired form, reducing their utility. Here we introduce PairedAbNGS, a novel database with paired heavy/light antibody chains. To the best of our know...

Topics

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• Computational Biology
• Genetic Variation
• Glycosylation and Glycoproteins Research
• High-Throughput Nucleotide Sequencing
• Immunoglobulin Heavy Chains
• Immunoglobulin Light Chains
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

b9555e6e-ece9-5a95-8cf0-b5a2ecb282c3

DOI

10.1101/2024.12.20.629642