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Development of an HiBiT‐tagged reporter H3N2 influenza A virus and its utility as an antiviral screening platform

24 Nov 2022

Abstract excerpt

The balance of the segmented genome derived from naturally occurring influenza A viruses (IAVs) is delicate and vulnerable to foreign insertions, thus most reporter IAVs up to date are generated using the backbone of the laboratory-adapted strains. In this study, we constructed a reporter influenza A/H3N2 virus (A/NY-HiBiT) which was derived from a clinical isolate, by placing a minimized HiBiT tag to the...

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PMID: 36424458
DOI: 10.1002/jmv.28345

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