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Spatially organized inflammatory myeloid-CD8 <sup>+</sup> T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment

2025-06-06

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive skin cancer with high propensity for metastasis, caused by Merkel-cell-polyomavirus (MCPyV), or chronic UV-light-exposure. How MCPyV spatially modulates immune responses within the tumor microenvironment and how such are linked to patient outcomes remains unknown. We interrogated the cellular and transcriptional landscapes of 60 MCC-patients using a combination of multi...

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Literature Corpus work
69a7b019-e722-59e9-bfa9-54482c5b1552
DOI
10.1101/2025.06.06.657162
Open publication

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