Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy

26 Jul 2024

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with a ∼50% response rate to immune checkpoint blockade (ICB) therapy. To identify predictive biomarkers, we integrated bulk and single-cell RNA sequencing (RNA-seq) with spatial transcriptomics from a cohort of 186 samples from 116 patients, including bulk RNA-seq from 14 matched pairs pre- and post-ICB. In nonresponders, tumors show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antenna Design and Analysis
Share to Plant Virus Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39058036
DOI: 10.1158/2159-8290.cd-23-0798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy EfficacyPMID 39058036Read ↗

Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilitiesSemantic proximity Read ↗

Spatially organized inflammatory myeloid-CD8 <sup>+</sup> T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor MicroenvironmentSemantic proximity Read ↗

Danger is only skin deep: aggressive epidermal carcinomas. An overview of the diagnosis, demographics, molecular-genetics, staging, prognostic biomarkers, and therapeutic advances in Merkel cell carcinoma.Semantic proximity Read ↗

Transcriptomic analyses reveal three distinct molecular subgroups of Merkel cell carcinoma with differing prognosesSemantic proximity Read ↗

Merkel cell carcinoma: an updated overview of clinico-pathological aspects, molecular genetics and therapy.Semantic proximity Read ↗

Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.Semantic proximity Read ↗

Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental featuresSemantic proximity Read ↗

Merkel cell carcinoma in southern China: clinicopathologic and transcriptomic analysis with insights into an intraepidermal-predominant lesionSemantic proximity Read ↗

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinomaSemantic proximity Read ↗

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell CarcinomaSemantic proximity Read ↗

Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival.Semantic proximity Read ↗

Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.