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Article

Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.

Cancer immunology research - 1 Feb 2017

Miller Natalie J, Church Candice D, Dong Lichun, Crispin David, Fitzgibbon Matthew P, Lachance Kristina, Jing Lichen, Shinohara Michi, Gavvovidis Ioannis, Willimsky Gerald, McIntosh Martin, Blankenstein Thomas, Koelle David M, Nghiem Paul

Abstract excerpt

Tumor-infiltrating CD8+ T cells are associated with improved survival of patients with Merkel cell carcinoma (MCC), an aggressive skin cancer causally linked to Merkel cell polyomavirus (MCPyV). However, CD8+ T-cell infiltration is robust in only 4% to 18% of MCC tumors. We characterized the T-cell receptor (TCR) repertoire restricted to one prominent epitope of MCPyV (KLLEIAPNC, "KLL") and assessed whether TCR...

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Share to Carcinoma, Merkel Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

Share to Lymphocytes, Tumor-Infiltrating

Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 28093446
DOI: 10.1158/2326-6066.CIR-16-0210
PMCID: PMC5421625

Genes

MCC
TRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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