Article

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling <i>in vivo</i>

2022-12-21

Abstract excerpt

Suppressor Of Cytokine Signaling (SOCS) 1 is a critical negative regulator of cytokine signaling and required to protect against an excessive inflammatory response. Genetic deletion of Socs1 results in unrestrained cytokine signaling and neonatal lethality, characterised by an inflammatory immune infiltrate in multiple organs. Overexpression and structural studies have suggested that the SOCS1 kinase inhibitory r...

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Identifiers and source

Literature Corpus work: 69986677-ac5f-5396-ad87-9da96d842425
DOI: 10.1101/2022.12.20.521329

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