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Article

Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011

Collins Erin L, Jager Lindsey D, Dabelic Rea, Benitez Patrick, Holdstein Kaitlin, Lau Kenneth, Haider Mohammed I, Johnson Howard M, Larkin Joseph

Abstract excerpt

Suppressor of cytokine signaling 1-deficient (SOCS1(-/-)) mice, which are lymphopenic, die <3 wk after birth of a T cell-mediated autoimmune inflammatory disease characterized by leukocyte infiltration and destruction of vital organs. Notably, Foxp3(+) regulatory T cells (Tregs) have been shown to be particularly potent in inhibiting inflammation-associated autoimmune diseases. We observed that SOCS1(-/-) mice...

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Identifiers

PMID: 21788442
DOI: 10.4049/jimmunol.1003819
PMCID: PMC3159835

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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