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Article

The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants.

eLife - 18 Oct 2024

Giunti Sebastián, Blanco María Gabriela, De Rosa María José, Rayes Diego

Abstract excerpt

A finely tuned balance between excitation and inhibition (E/I) is essential for proper brain function. Disruptions in the GABAergic system, which alter this equilibrium, are a common feature in various types of neurological disorders, including autism spectrum disorders (ASDs). Mutations in Phosphatase and Tensin Homolog (PTEN), the main negative regulator of the phosphatidylinositol 3-phosphate kinase/Akt...

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PMID: 39422188
DOI: 10.7554/eLife.94520
PMCID: PMC11488850

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