Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants.

doi:10.3791/837

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Article

Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants.

Journal of visualized experiments : JoVE - 18 Aug 2008

Locke Cody, Berry Kalen, Kautu Bwarenaba, Lee Kyle, Caldwell Kim, Caldwell Guy

Abstract excerpt

The nematode, Caenorhabditis elegans, has become an expedient model for studying neurotransmission. C. elegans is unique among animal models, as the anatomy and connectivity of its nervous system has been determined from electron micrographs and refined by pharmacological assays. In this video, we describe how two complementary neural stimulants, an acetylcholinesterase inhibitor, called aldicarb, and a...

Topics

Aldicarb
Animals
Caenorhabditis elegans
Cholinesterase Inhibitors
GABA Antagonists
Models, Animal
Mutation
Pentylenetetrazole
Synaptic Transmission

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Identifiers

PMID: 19066504
DOI: 10.3791/837
PMCID: PMC2762817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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