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Article

<i>TigarB</i> causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

12 Aug 2013

Abstract excerpt

OBJECTIVE: Loss of function mutations in PINK1 typically lead to early onset Parkinson disease (PD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study neurodegenerative diseases. We used a pink1 mutant (pink(-/-) ) zebrafish line with a premature stop mutation (Y431*) in the PINK1 kinase domain to identify molecular mechanisms leading to mitochondrial dysfunction and loss of...

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PMID: 24027110
DOI: 10.1002/ana.23999

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