Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclometalated iridium( <scp>iii</scp> ) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth <i>in vivo</i>

1 Jan 2018

Abstract excerpt

The development of iridium complexes as potent anticancer agents has received increasing attention in recent years. In this study, four cyclometalated Ir(iii) complexes with good photophysical properties and potent anticancer activity have been synthesized and characterized. They are taken up by human lung adenocarcinoma A549 cells very quickly and specifically target mitochondria. Mechanism studies reveal that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Metal complexes synthesis and properties
Share to Nanoplatforms for cancer theranostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29721561
DOI: 10.1039/c8dt00783g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclometalated iridium( <scp>iii</scp> ) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth <i>in vivo</i>PMID 29721561Read ↗

A New Strategy to Fight Metallodrug Resistance: Mitochondria‐Relevant Treatment through Mitophagy to Inhibit Metabolic Adaptations of Cancer CellsSemantic proximity Read ↗

Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cellsSemantic proximity Read ↗

DNA-Unresponsive Platinum(II) Complex Induces ERS-Mediated Mitophagy in Cancer CellsSemantic proximity Read ↗

Metallodrugs: an approach against invasion and metastasis in cancer treatmentSemantic proximity Read ↗

Metal-based anticancer drugs: From a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biologySemantic proximity Read ↗

A rhodamine-coordinated iridium complex to overcome cisplatin-resistant cancer via regulating mitochondrial function triggered apoptosis and ferroptosisSemantic proximity Read ↗

Cellular Discrepancy of Platinum Complexes in Interfering with Mitochondrial DNASemantic proximity Read ↗

Progress of Metal‐Based Anticancer Chemotherapeutic Agents in Last two Decades and their Comprehensive Biological (DNA/RNA Binding, Cleavage and Cytotoxicity Activity) StudiesSemantic proximity Read ↗

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeuticsSemantic proximity Read ↗

Multifunctional AIE Iridium (III) Photosensitizer Nanoparticles for Two-Photon-Activated Imaging and Mitochondria Targeting Photodynamic TherapySemantic proximity Read ↗

Fresh Platinum Complexes with Promising Antitumor ActivitySemantic proximity Read ↗

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.