Article

Genetic variation underlies ancestry-associated DNA methylation differences with immune regulatory potential in breast tumors

2026-08-18

Abstract excerpt

Population differences in breast cancer outcomes may reflect ancestry-linked genetic and molecular variation. Yet, how population-related genetic variation shapes tumor epigenetic and transcriptomic patterns remains unclear. Here, analyzing breast tumors of predominantly African and European genetic ancestry from The Cancer Genome Atlas, we identify 747 ancestry-associated differentially methylated sites. Methylat...

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Literature Corpus work: 750d7fc2-722f-5b0f-add8-db47d070f414
DOI: 10.1038/s42003-026-10784-x

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