Article

GLP-1R agonists activate human hypothalamic neurons

2024-04-03

Abstract excerpt

Drugs like semaglutide (a.k.a. Ozempic/Wegovy) that activate the glucagon-like peptide-1 receptor (GLP-1R) are a promising therapy for obesity and type 2 diabetes (T2D). Animal studies suggest that these drugs likely function by stimulating GLP-1R on appetite-suppressing neuron populations in the brain, but it is still unclear how they act to reduce food intake in humans. We therefore generated appetite-regulatory...

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Literature Corpus work: 696013f7-5521-5f0c-9868-57c7e009b640
DOI: 10.1101/2024.04.02.587825

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