Article
Functional heterogeneity of POMC neurons relies on mTORC1 signaling.
Cell reports - 12 Oct 2021
Saucisse Nicolas, Mazier Wilfrid, Simon Vincent, Binder Elke, Catania Caterina, Bellocchio Luigi, Romanov Roman A, Léon Stéphane, Matias Isabelle, Zizzari Philippe, Quarta Carmelo, Cannich Astrid, Meece Kana, Gonzales Delphine, Clark Samantha, Becker Julia M, Yeo Giles S H, Fioramonti Xavier, Merkle Florian T, Wardlaw Sharon L, Harkany Tibor, Massa Federico, Marsicano Giovanni, Cota Daniela
Abstract excerpt
Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), glutamate, or both neurotransmitters, whose functions are poorly defined. Using conditional mutagenesis and chemogenetics, we show that blockade of the energy sensor mechanistic target of rapamycin complex 1 (mTORC1) in POMC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.