Article

Mutation of two intronic nucleotides alters RNA structure and dynamics inhibiting MBNL1 and RBFOX1 regulated splicing of the Insulin Receptor

2024-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Alternative splicing (AS) of Exon 11 of the Insulin Receptor ( INSR ) is highly regulated and disrupted in several human disorders. To better understand INSR exon 11 AS regulation, splicing activity of an INSR exon 11 minigene reporter was measured across a gradient of the AS regulator muscleblind-like 1 protein (MBNL1). The RNA-binding protein Fox-1 (RBFOX1) was added to determine its impact...

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Literature Corpus work: 695f3c58-4be7-5d8d-9eb0-5963cfb1369e
DOI: 10.1101/2024.01.08.574689

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