Article
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.
PloS one - 1 Jan 2011
Talukdar Indrani, Sen Supriya, Urbano Rodolfo, Thompson James, Yates John R, Webster Nicholas J G
Abstract excerpt
Exon 11 of the insulin receptor gene (INSR) is alternatively spliced in a developmentally and tissue-specific manner. Linker scanning mutations in a 5' GA-rich enhancer in intron 10 identified AGGGA sequences that are important for enhancer function. Using RNA-affinity purification and mass spectrometry, we identified hnRNP F and hnRNP A1 binding to these AGGGA sites and also to similar motifs at the 3' end of...
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