Article

Regulation of FXR1 by alternative splicing is required for muscle development and controls liquid-like condensates in muscle cells

2019-10-24

Abstract excerpt

<h4>SUMMARY</h4> Fragile-X mental retardation autosomal homolog-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple protein isoforms and mis-splicing has been implicated in disease. Furthermore, mutations that cause...

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Literature Corpus work: b91338c7-fb20-5216-9426-8ff3ee555051
DOI: 10.1101/818476

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